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Joint/recent publications of SPP 1710 members


Suzuki S, Schwartz SL, Mueller NC, Schmitt MJ (2017) Cysteine residues in a yeast viral A/B toxin crucially control host cell killing via pH-triggered disulfide rearrangements. Mol. Biol. Cell doi:10.1091/mbc.E16-12-0842.





Gutsche N, Thurow C, Zachgo S, Gatz C (2015) Plant-specific CC-type glutaredoxins: functions in developmental processes and stress responses. Biol Chem 396, 495-509

Herrmann JM, Becker K, Dick TP (2015) Highlight: Dynamics of thiol-based redox switches: The many faces of thiol switches (Editorial)Biol Chem 396, 385-387

Rahbari M, Diederich K, Becker K, Krauth-Siegel RL, Jortzik E (2015) Detection of thiol-based redox switch processes in parasites – facts and future Biol Chem 396, 445-463 (invited review)

Mohring F, Jortzik E, Becker K (2015) Comparison of methods probing the intracellular redox milieu in Plasmodium falciparum. Mol Biochem Parasitol, in press

Tyagi C, Bathke J, Goyal S, Fischer M, Dahse HM, Chacko S, Becker K and Grover A (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence Internat J Biochem Cell Biol 61, 72-80

Berndt C, Schwenn J.D, and Lillig CH (2015)The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric complementarity.Chem. Sci., accepted, DOI: 10.1039/C5SC01501D

Berndt C, and Lillig CH (2015) Redox regulation of differentiation and de-differentiation Biochim. Biophys. Acta-General subjects 1850: 1467-1468

Gellert M, Hanschmann EM, Lepka K, Berndt C and Lillig CH (2015) Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation. Biochim. Biophys. Acta-General subjects 1850: 1575-1587

Hildebrandt T, Knuesting J, Berndt C, Morgan B, Scheibe R (2015) Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub? Biol Chem. 396: 523-537

Schaffroth C, Bogacz M, Dirdjaja N, Nißen A, Krauth-Siegel  RL (2015)The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis. Mol Microbiol. doi: 10.1111/mmi.13223. [Epub ahead of print]

Wagner S, Behera S, De Bortoli S, Logan DC, Fuchs P, Carraretto L, Teardo E, Cendron L, Nietzel T, Füßl M, Doccula FG, Navazio L, Fricker MD, Van Aken O, Finkemeier I, Meyer AJ, Szabo I, Costa A, Schwarzländer M (2015) The EF-hand Ca2+-binding protein MICU choreographs mitochondrial Ca2+ dynamics in Arabidopsis. Plant Cell. e-published ahead of print, doi:10.1105/tpc.15.00509

Schwarzländer M, Dick TP, Meyer AJ, Morgan B (2015) Dissecting redox biology using fluorescent protein sensors. Antiox Redox Signal. e-published ahead of print, doi:10.1089/ars.2015.6266

Gray MJ, Li Y, Leichert LI, Xu Z, Jakob U (2015) Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Antioxid Redox Signal. 2015 Sep 20;23(9):747-754.PMID: 25867078

Leichert LI, Dick TP (2015) Incidence and physiological relevance of protein thiol switches.
Biol Chem. 2015 May;396(5):389-399.PMID: 25719318

Moseler A, Aller I, Wagner S, Nietzel T, Przybyla-Toscano J, Mühlenhoff U, Lill R, Berndt C, Rouhier N, Schwarzländer M, Meyer AJ (2015) The mitochondrial monothiol glutaredoxin S15 is essential for maturation of iron-sulfur proteins in Arabidopsis thaliana. Proc Natl Acad Sci USA. 112 (44): 13735-13740

Wagner S, Nietzel T, Aller I, Costa A, Fricker MD, Meyer AJ, Schwarzländer M ( (2015) Analysis of plant mitochondrial function using fluorescent protein sensors. Methods Mol Biol. 1305: 241-252

Riemer J, Schwarzländer M, Conrad M, Herrmann JM (2015) Thiol switches in mitochondria: operation and physiological relevance. Biol Chem. 396 (5): 465-482

Kosmacz M, Parlanti S, Schwarzländer M, Kragler F, Licausi F, Van Dongen JT (2015) The stability and nuclear localization of the transcription factor RAP2.12 are dynamically regulated by oxygen concentration. Plant Cell Environ. 38 (6): 1094-1103

Dick TP, Ralser M (2015) Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?
Mol Cell 59:519-521

Herrmann JM, Becker K, Dick TP (2015) Highlight: dynamics of thiol-based redox switches. Biol Chem 396:385-387

Greiner R, Dick TP (2015) Real-time assays for monitoring the influence of sulfide and sulfane sulfur species on protein thiol redox states. Methods Enzymol 555:57-77

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD (2015) Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520:549-552

Rucker H, Al-Rifai N, Rascle A, Gottfried E, Brodziak-Jarosz L, Gerhauser C,Dick TP, Amslinger S (2015) Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site. Org Biomol Chem 13:3040-3047

Peralta D, Bronowska AK, Morgan B, Doka E, Van Laer K, Nagy P, Grater F, Dick TP (2015) A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nat Chem Biol 11:156-163

Sobotta MC, Liou W, Stocker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol 11:64-70

Dietz K-J, Hell R (2015) Thiol switches in redox regulation of chloroplasts: balancing redox state, metabolism and oxidative stress. Biol Chem 396,483–494, doi: 10.1515/hsz-2014-0281

Speiser A, Haberland H, Watanabe M, Wirtz M, Dietz K-J, Saito K, Hell R (2015) The significance of cysteine synthesis for acclimation to high light conditions. Front Plant Sci 5, 775; doi: 10.3389/fpls.2014.00776

Knuesting J, Riondet C, Maria C, Kruse I, Bécuwe N, König N, Berndt C, Tourrette S, Guilleminot-Montoya J, Herrero E, Gaymard F, Balk J, Belli G, Scheibe R, Reichheld J. P, Rouhier N, and Rey P. (2015) Arabidopsis glutaredoxin S17 and its partner NF-YC11/NC2α contribute to maintenance of the shoot apical meristem under long-day photoperiod. Plant Physiology 167: 1643-1658



Schaedler TA, Thornton JD, Kruse I, Schwarzländer M, Meyer AJ, van Veen HW, Balk J (2014) A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly. J Biol Chem. 289 (34): 23264-23274

Schwarzlander M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Muller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP (2014) The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514:E12-14

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK (2014) Reactivation of oxidized PTP1B and PTEN by thioredoxin 1. FEBS J 281:3545-3558

Breckwoldt MO, Pfister FM, Bradley PM, Marinkovic P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzlander M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T(2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med 20:555-560

Ezerina D, Morgan B, Dick TP (2014) Imaging dynamic redox processes with genetically encoded probes.
J Mol Cell Cardiol 73:43-49

Birke H, De Kok LJ, Wirtz M, Hell R (2014) The role of compartment-specific cysteine synthesis for sulfur homeostasis during H2S exposure in Arabidopsis. Plant Cell Physiol 56, 358-67. doi: 10.1093/pcp/pcu166

Albrecht SC, Sobotta MC, Bausewein D, Aller I, Hell R, Dick TP, Meyer AJ (2014) Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes. J Biomol Screen 19, 379-386

Berndt C, Lillig CH, Flohe L (2014)Redox regulation by glutathione needs enzymes. Front. Pharmacol, doi: 10.3389/fphar.2014.00168

Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U (2014) The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Mol Cell. 2014 Oct 2;56(1):116-27. doi: 10.1016/j.molcel.2014.08.017. Epub 2014 Sep 18

Elbaz-Alon Y, Morgan B, Clancy A,  Amoako TN,  Zalckvar E, Dick TP, Schwappach B, Schuldiner M (2014) The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis. FEMS Yeast Res. 2014 Nov;14(7):1055-67. doi: 10.1111/1567-1364.12196. Epub 2014 Sep 22

Knoefler D, Leichert LI, Thamsen M, Cremers CM, Reichmann D, Gray MJ, Wholey WY, Jakob U (2014) About the dangers, costs and benefits of living an aerobic lifestyle. Biochem Soc Trans. 2014 Aug;42(4):917-921,PMID: 25109979

Littlejohn G, Meckel T, Schwarzländer M, Costa A (2014) Functional imaging in living plants – cell biology meets physiology. Front Plant Sci 5:740

Braun H-P, Binder S, Brennicke A, Eubel H, Fernie AR, Finkemeier I, Klodmann J, König A-C, Kühn K, Meyer E, Obata T, Schwarzländer M, Takenaka M, Zehrmann A (2014) The life of plant mitochondrial complex I. Mitochondrion. 19 (B): 295-313

El Zawily AM, Schwarzländer M, Finkemeier I, Johnston IG, Benamar A, Cao Y, Gissot C, Meyer AJ, Wilson K, Datla R, Macherel D, Jones NS, Logan DC (2014) FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis. Plant Physiol. 166 (2): 808-828



Sobotta MC, Barata AG, Schmidt U, Mueller S, Millonig G, Dick TP (2013) Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments. Free Radic Biol Med 60:325-335

Wittig R, Richter V, Wittig-Blaich S, Weber P, Strauss WS, Bruns T, Dick TP, Schneckenburger H (2013) Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions. J Biomol Screen 18:736-743

Birk J, Meyer M, Aller I, Hansen HG, Odermatt A, Dick TP, Meyer AJ, Appenzeller-Herzog C (2013) Endoplasmic reticulum: reduced and oxidized glutathione revisited. J Cell Sci 126:1604-1617

Gibbs-Flournoy EA, Simmons SO, Bromberg PA, Dick TP, Samet JM (2013) Monitoring intracellular redox changes in ozone-exposed airway epithelial cells. Environ Health Perspect 121:312-317

Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM (2013)

Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal 18, 1597-1612

Eckers E, Petrungaro C, Groß D, Riemer J, Hell K, Deponte M (2013) Divergent molecular evolution of the mitochondrial sulfhydryl: cytochrome c oxidoreductase Erv in opisthokonts and parasitic protists. J Biol Chem 288, 2676-88

Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, Dick TP (2013) Polysulfides Link H2S to Protein Thiol Oxidation. Antioxid Redox Signal 19, 1749-65

Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R, Berndt C, Lillig CH (2013) Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell 24, 1895-1903

Kasozi D, Rahlfs S, Mohring F, Meyer AJ, Becker K (2013) Real-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparum. PLoS Pathogens e1003782

Lill R, Berndt C, Lillig CH, Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U (2013) Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell 24, 1895-1903

Lillig CH, Berndt C (2013) Cellular functions of glutathione. Biochim Biophys Acta 1830, 3137-3138

Lillig CH, Berndt C (2013) Glutaredoxins in thiol/disulfide exchange. Antioxid Redox Signal 18, 1654-1665

Manta B, Pavan C, Sturlese M, Medeiros A, Crispo M, Berndt C, Krauth-Siegel RL, Bellanda M, Comini MA (2013) Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity. Antioxid Redox Signal 19, 665-682. PMID:23259530

Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.Nat Chem Biol 9, 119-125

Zachgo S, Hanke GH, Scheibe R (2013) Plant cell microcompartments: A redox perspective.Biol. Chem. 2013, 394 203-216

Barata AG,Dick TP (2013) In vivo imaging of H2O2 production in Drosophila. Methods Enzymol 526:61-82



Herrmann JM, Dick TP (2012) Redox Biology on the rise. Biol Chem 393, 999-1004

Kojer K, Bien M, Gangel H, Morgan B, Dick TP, Riemer J (2012) Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J 31, 3169-3182

Schwarzlander M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Muller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ (2012) Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol 22, 503-508



Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A, Lillig CH, Berndt C (2011) Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci USA 108, 20532-20537

Hoffmann B, Uzarska MA, Berndt C, Godoy JR, Haunhorst P, Lillig CH, Lill R, Mühlenhoff U (2011) The multidomain thioredoxin-monothiol glutaredoxins represent a distinct functional group. Antioxid Redox Signal 15, 19-30. PMID: 21299470

Kehr S, Jortzik E, Delahunty C, Yates III JR, Rahlfs S, Becker K (2011) Protein S-glutathionylation in malaria parasites. Antiox Redox Signal 15, 2855-2865

Lillig CH, Berndt C, Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A (2011) Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci USA 108, 20532-20537



Braun NA, Morgan B, Dick TP, Schwappach B (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J Cell Sci 123, 2342-2350

Ceylan S, Seidel V, Ziebart N, Berndt C, Dirdjaja N, Krauth-Siegel RL (2010) The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism. J Biol Chem 285, 35224-35237. PMID: 20826822

Maughan SC, Pasternak M, Cairns N, Kiddle G, Brach T, Jarvis R, Haas F, Nieuwland J, Lim B, Müller C, Salcedo-Sora E, Kruse C, Orsel M, Hell R, Miller AJ, Bray P, Murray JAH, Foyer CH, Meyer AJ, Cobbett CS (2010) Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Proc Natl Acad Sci USA 107, 2331-2336

Meyer AJ, Dick TP (2010) Fluorescent protein-based redox probes. Antioxid Redox Signal 13, 621-650

Khan MS, Haas F, Allboje Samami A, Moghaddas Gholami A, Bauer A, Fellenberg K, Reichelt M, Hänsch R, Mendel R, Meyer AJ, Wirtz M, Hell R (2010) Sulfite reductase defines a new bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana. Plant Cell 22, 1216-1231



Eckers E, Bien M, Stroobant V, Herrmann JM, Deponte M (2009)

Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: The catalytic redox mechanism redux. Biochemistry 48, 1410-23

Marty L, Siala W, Schwarzländer M, Fricker MD, Wirtz M, Sweetlove LJ, Meyer Y, Meyer AJ, Reichheld JP, Hell R (2009) The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis. PNAS 106, 9109-9114

Gutscher M, Sobotta MC, Wabnitz GH, Ballikaya S, Meyer AJ, Samstag Y, Dick TP (2009)

Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases. J Biol Chem 284, 31532-31540

Riemer J, Bulleid N, Herrmann JM (2009) Disulfide formation in the ER and mitochondria: two solutions to a common process. Science 324, 1284-1287



Comini MA, Rettig J, Dirdjaja N, Hanschmann EM, Berndt C, Krauth-Siegel RL (2008) Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes. J Biol Chem 283(41), 27785-27798. PMID: 18669638

Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real-time imaging of the intracellular glutathione redox potential. Nat Methods 5, 553-559

Leichert LI, Gehrke F, Gudiseva HV, Blackwell T, Ilbert M, Walker AK, Strahler JR, Andrews PC, Jakob U (2008) Quantifying changes in the thiol redox proteome upon oxidative stress in vivo.Proc Natl Acad Sci USA 105, 8197-8202