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Joint/recent publications of SPP 1710 members

2017

Suzuki S, Schwartz SL, Mueller NC, Schmitt MJ (2017) Cysteine residues in a yeast viral A/B toxin crucially control host cell killing via pH-triggered disulfide rearrangements. Mol. Biol. Cell doi:10.1091/mbc.E16-12-0842.

 

2016

 

2015

    Gutsche N, Thurow C, Zachgo S, Gatz C (2015) Plant-specific CC-type glutaredoxins: functions in developmental processes and stress responses. Biol Chem 396, 495-509

    Herrmann JM, Becker K, Dick TP (2015) Highlight: Dynamics of thiol-based redox switches: The many faces of thiol switches (Editorial)Biol Chem 396, 385-387

    Rahbari M, Diederich K, Becker K, Krauth-Siegel RL, Jortzik E (2015) Detection of thiol-based redox switch processes in parasites – facts and future Biol Chem 396, 445-463 (invited review)

    Mohring F, Jortzik E, Becker K (2015) Comparison of methods probing the intracellular redox milieu in Plasmodium falciparum. Mol Biochem Parasitol, in press

    Tyagi C, Bathke J, Goyal S, Fischer M, Dahse HM, Chacko S, Becker K and Grover A (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence Internat J Biochem Cell Biol 61, 72-80

    Berndt C, Schwenn J.D, and Lillig CH (2015)The specificity of thioredoxins and glutaredoxins is determined by electrostatic and geometric complementarity.Chem. Sci., accepted, DOI: 10.1039/C5SC01501D

    Berndt C, and Lillig CH (2015) Redox regulation of differentiation and de-differentiation Biochim. Biophys. Acta-General subjects 1850: 1467-1468

    Gellert M, Hanschmann EM, Lepka K, Berndt C and Lillig CH (2015) Redox regulation of cytoskeletal dynamics during differentiation and de-differentiation. Biochim. Biophys. Acta-General subjects 1850: 1575-1587

    Hildebrandt T, Knuesting J, Berndt C, Morgan B, Scheibe R (2015) Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub? Biol Chem. 396: 523-537 http://www.ncbi.nlm.nih.gov/pubmed/25581756

    Schaffroth C, Bogacz M, Dirdjaja N, Nißen A, Krauth-Siegel  RL (2015)The cytosolic or the mitochondrial glutathione peroxidase-type tryparedoxin peroxidase is sufficient to protect procyclic Trypanosoma brucei from iron-mediated mitochondrial damage and lysis. Mol Microbiol. doi: 10.1111/mmi.13223. [Epub ahead of print]

    Wagner S, Behera S, De Bortoli S, Logan DC, Fuchs P, Carraretto L, Teardo E, Cendron L, Nietzel T, Füßl M, Doccula FG, Navazio L, Fricker MD, Van Aken O, Finkemeier I, Meyer AJ, Szabo I, Costa A, Schwarzländer M (2015) The EF-hand Ca2+-binding protein MICU choreographs mitochondrial Ca2+ dynamics in Arabidopsis. Plant Cell. e-published ahead of print, doi:10.1105/tpc.15.00509

    Schwarzländer M, Dick TP, Meyer AJ, Morgan B (2015) Dissecting redox biology using fluorescent protein sensors. Antiox Redox Signal. e-published ahead of print, doi:10.1089/ars.2015.6266

    Gray MJ, Li Y, Leichert LI, Xu Z, Jakob U (2015) Does the Transcription Factor NemR Use a Regulatory Sulfenamide Bond to Sense Bleach? Antioxid Redox Signal. 2015 Sep 20;23(9):747-754.PMID: 25867078

    Leichert LI, Dick TP (2015) Incidence and physiological relevance of protein thiol switches.
    Biol Chem. 2015 May;396(5):389-399.PMID: 25719318

    MoselerA, Aller I, Wagner S, Nietzel T, Przybyla-Toscano J, Mühlenhoff U, Lill R, Berndt C, Rouhier N, Schwarzländer M, Meyer AJ (2015) The mitochondrial monothiol glutaredoxin S15 is essential for maturation of iron-sulfur proteins in Arabidopsis thaliana. Proc Natl Acad Sci USA. 112 (44): 13735-13740

    Wagner S, Nietzel T, Aller I, Costa A, Fricker MD, Meyer AJ, Schwarzländer M ( (2015) Analysis of plant mitochondrial function using fluorescent protein sensors. Methods Mol Biol. 1305: 241-252

    Riemer J, Schwarzländer M, Conrad M, Herrmann JM (2015) Thiol switches in mitochondria: operation and physiological relevance. Biol Chem. 396 (5): 465-482

    KosmaczM, ParlantiS, SchwarzländerM, KraglerF, LicausiF, Van Dongen JT (2015) The stability and nuclear localization of the transcription factor RAP2.12 are dynamically regulated by oxygen concentration. Plant Cell Environ. 38 (6): 1094-1103

    Dick TP, Ralser M (2015) Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow?
    Mol Cell 59:519-521

    Herrmann JM, Becker K, Dick TP (2015) Highlight: dynamics of thiol-based redox switches. Biol Chem 396:385-387

    Greiner R, Dick TP (2015) Real-time assays for monitoring the influence of sulfide and sulfane sulfur species on protein thiol redox states. Methods Enzymol 555:57-77

    Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD (2015) Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520:549-552

    Rucker H, Al-Rifai N, Rascle A, Gottfried E, Brodziak-Jarosz L, Gerhauser C,Dick TP, Amslinger S (2015) Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site. Org Biomol Chem 13:3040-3047

    Peralta D, Bronowska AK, Morgan B, Doka E, Van Laer K, Nagy P, Grater F, Dick TP (2015) A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nat Chem Biol 11:156-163

    Sobotta MC, Liou W, Stocker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol 11:64-70

    Dietz K-J, Hell R (2015) Thiol switches in redox regulation of chloroplasts: balancing redox state, metabolism and oxidative stress. Biol Chem 396,483–494, doi: 10.1515/hsz-2014-0281

    Speiser A, Haberland H, Watanabe M, Wirtz M, Dietz K-J, Saito K, Hell R (2015) The significance of cysteine synthesis for acclimation to high light conditions. Front Plant Sci 5, 775; doi: 10.3389/fpls.2014.00776

    Knuesting J, Riondet C, Maria C, Kruse I, Bécuwe N, König N, Berndt C, Tourrette S, Guilleminot-Montoya J, Herrero E, Gaymard F, Balk J, Belli G, Scheibe R, Reichheld J. P, Rouhier N, and Rey P. (2015) Arabidopsis glutaredoxin S17 and its partner NF-YC11/NC2α contribute to maintenance of the shoot apical meristem under long-day photoperiod. Plant Physiology 167: 1643-1658

     

    2014

    Schaedler TA, Thornton JD, Kruse I, Schwarzländer M, Meyer AJ, van Veen HW, Balk J (2014) A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly. J Biol Chem. 289 (34): 23264-23274

    Schwarzlander M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Muller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP (2014) The 'mitoflash' probe cpYFP does not respond to superoxide. Nature 514:E12-14

    Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK (2014) Reactivation of oxidized PTP1B and PTEN by thioredoxin 1. FEBS J 281:3545-3558

    Breckwoldt MO, Pfister FM, Bradley PM, Marinkovic P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzlander M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T(2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med 20:555-560

    Ezerina D, Morgan B, Dick TP (2014) Imaging dynamic redox processes with genetically encoded probes.
    J Mol Cell Cardiol 73:43-49

    Birke H, De Kok LJ, Wirtz M, Hell R (2014) The role of compartment-specific cysteine synthesis for sulfur homeostasis during H2S exposure in Arabidopsis. Plant Cell Physiol 56, 358-67. doi: 10.1093/pcp/pcu166

    Albrecht SC, Sobotta MC, Bausewein D, Aller I, Hell R, Dick TP, Meyer AJ (2014) Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes. J Biomol Screen 19, 379-386

    Berndt C, Lillig CH, Flohe L (2014)Redox regulation by glutathione needs enzymes. Front. Pharmacol, doi: 10.3389/fphar.2014.00168

    Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U (2014) The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Mol Cell. 2014 Oct 2;56(1):116-27. doi: 10.1016/j.molcel.2014.08.017. Epub 2014 Sep 18

    Elbaz-Alon Y, Morgan B, Clancy A,  Amoako TN,  Zalckvar E, Dick TP, Schwappach B, Schuldiner M (2014) The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis. FEMS Yeast Res. 2014 Nov;14(7):1055-67. doi: 10.1111/1567-1364.12196. Epub 2014 Sep 22

    Knoefler D, Leichert LI, Thamsen M, Cremers CM, Reichmann D, Gray MJ, Wholey WY, Jakob U (2014) About the dangers, costs and benefits of living an aerobic lifestyle. Biochem Soc Trans. 2014 Aug;42(4):917-921,PMID: 25109979

    Littlejohn G, Meckel T, Schwarzländer M, Costa A (2014) Functional imaging in living plants – cell biology meets physiology. Front Plant Sci 5:740

    Braun H-P, Binder S, Brennicke A, Eubel H, Fernie AR, Finkemeier I, Klodmann J, König A-C, Kühn K, Meyer E, Obata T, SchwarzländerM, Takenaka M, Zehrmann A (2014) The life of plant mitochondrial complex I. Mitochondrion. 19 (B): 295-313

    El Zawily AM, Schwarzländer M, Finkemeier I, Johnston IG, Benamar A, Cao Y, Gissot C, Meyer AJ, Wilson K, Datla R, Macherel D, Jones NS, Logan DC (2014) FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis. Plant Physiol. 166 (2): 808-828

     

    2013

    Sobotta MC, Barata AG, Schmidt U, Mueller S, Millonig G, Dick TP (2013) Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments. Free Radic Biol Med 60:325-335

    Wittig R, Richter V, Wittig-Blaich S, Weber P, Strauss WS, Bruns T, Dick TP, Schneckenburger H (2013) Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions. J Biomol Screen 18:736-743

    Birk J, Meyer M, Aller I, Hansen HG, Odermatt A, Dick TP, Meyer AJ, Appenzeller-Herzog C (2013) Endoplasmic reticulum: reduced and oxidized glutathione revisited. J Cell Sci 126:1604-1617

    Gibbs-Flournoy EA, Simmons SO, Bromberg PA, Dick TP, Samet JM (2013) Monitoring intracellular redox changes in ozone-exposed airway epithelial cells. Environ Health Perspect 121:312-317

    Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM (2013)

    Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal 18, 1597-1612

    Eckers E, Petrungaro C, Groß D, Riemer J, Hell K, Deponte M (2013) Divergent molecular evolution of the mitochondrial sulfhydryl: cytochrome c oxidoreductase Erv in opisthokonts and parasitic protists. J Biol Chem 288, 2676-88

    Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, Dick TP (2013) Polysulfides Link H2S to Protein Thiol Oxidation. Antioxid Redox Signal 19, 1749-65

    Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U, Lill R, Berndt C, Lillig CH (2013) Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell 24, 1895-1903

    Kasozi D, Rahlfs S, Mohring F, Meyer AJ, Becker K (2013) Real-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparum. PLoS Pathogens e1003782

    Lill R, Berndt C, Lillig CH, Haunhorst P, Hanschmann EM, Bräutigam L, Stehling O, Hoffmann B, Mühlenhoff U (2013) Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell 24, 1895-1903

    Lillig CH, Berndt C (2013) Cellular functions of glutathione. Biochim Biophys Acta 1830, 3137-3138

    Lillig CH, Berndt C (2013) Glutaredoxins in thiol/disulfide exchange. Antioxid Redox Signal 18, 1654-1665

    Manta B, Pavan C, Sturlese M, Medeiros A, Crispo M, Berndt C, Krauth-Siegel RL, Bellanda M, Comini MA (2013) Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity. Antioxid Redox Signal 19, 665-682. PMID:23259530

    Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.Nat Chem Biol 9, 119-125

    Zachgo S, Hanke GH, Scheibe R (2013) Plant cell microcompartments: A redox perspective.Biol. Chem. 2013, 394 203-216

    Barata AG,Dick TP (2013) In vivo imaging of H2O2 production in Drosophila. Methods Enzymol 526:61-82

     

    2012

    Herrmann JM, Dick TP (2012) Redox Biology on the rise. Biol Chem 393, 999-1004

    Kojer K, Bien M, Gangel H, Morgan B, Dick TP, Riemer J (2012) Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J 31, 3169-3182

    Schwarzlander M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Muller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ (2012) Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol 22, 503-508

     

    2011

    Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A, Lillig CH, Berndt C (2011) Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci USA 108, 20532-20537

    Hoffmann B, Uzarska MA, Berndt C, Godoy JR, Haunhorst P, Lillig CH, Lill R, Mühlenhoff U (2011) The multidomain thioredoxin-monothiol glutaredoxins represent a distinct functional group. Antioxid Redox Signal 15, 19-30. PMID: 21299470

    Kehr S, Jortzik E, Delahunty C, Yates III JR, Rahlfs S, Becker K (2011) Protein S-glutathionylation in malaria parasites. Antiox Redox Signal 15, 2855-2865

    Lillig CH, Berndt C, Bräutigam L, Schütte LD, Godoy JR, Prozorovski T, Gellert M, Hauptmann G, Holmgren A (2011) Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci USA 108, 20532-20537

     

    2010

    Braun NA, Morgan B, Dick TP, Schwappach B (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J Cell Sci 123, 2342-2350

    Ceylan S, Seidel V, Ziebart N, Berndt C, Dirdjaja N, Krauth-Siegel RL (2010) The dithiol glutaredoxins of african trypanosomes have distinct roles and are closely linked to the unique trypanothione metabolism. J Biol Chem 285, 35224-35237. PMID: 20826822

    Maughan SC, Pasternak M, Cairns N, Kiddle G, Brach T, Jarvis R, Haas F, Nieuwland J, Lim B, Müller C, Salcedo-Sora E, Kruse C, Orsel M, Hell R, Miller AJ, Bray P, Murray JAH, Foyer CH, Meyer AJ, Cobbett CS (2010) Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Proc Natl Acad Sci USA 107, 2331-2336

    Meyer AJ, Dick TP (2010) Fluorescent protein-based redox probes. Antioxid Redox Signal 13, 621-650

    Khan MS, Haas F, Allboje Samami A, Moghaddas Gholami A, Bauer A, Fellenberg K, Reichelt M, Hänsch R, Mendel R, Meyer AJ, Wirtz M, Hell R (2010) Sulfite reductase defines a new bottleneck for assimilatory sulfate reduction and is essential for growth and development in Arabidopsis thaliana. Plant Cell 22, 1216-1231

     

    2009

    Eckers E, Bien M, Stroobant V, Herrmann JM, Deponte M (2009)

    Biochemical characterization of dithiol glutaredoxin 8 from Saccharomyces cerevisiae: The catalytic redox mechanism redux. Biochemistry 48, 1410-23

    Marty L, Siala W, Schwarzländer M, Fricker MD, Wirtz M, Sweetlove LJ, Meyer Y, Meyer AJ, Reichheld JP, Hell R (2009) The NADPH-dependent thioredoxin system constitutes a functional backup for cytosolic glutathione reductase in Arabidopsis. PNAS 106, 9109-9114

    Gutscher M, Sobotta MC, Wabnitz GH, Ballikaya S, Meyer AJ, Samstag Y, Dick TP (2009)

    Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases. J Biol Chem 284, 31532-31540

    Riemer J, Bulleid N, Herrmann JM (2009) Disulfide formation in the ER and mitochondria: two solutions to a common process. Science 324, 1284-1287

     

    2008

    Comini MA, Rettig J, Dirdjaja N, Hanschmann EM, Berndt C, Krauth-Siegel RL (2008) Monothiol glutaredoxin-1 is an essential iron-sulfur protein in the mitochondrion of African trypanosomes. J Biol Chem 283(41), 27785-27798. PMID: 18669638

    Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real-time imaging of the intracellular glutathione redox potential. Nat Methods 5, 553-559

    Leichert LI, Gehrke F, Gudiseva HV, Blackwell T, Ilbert M, Walker AK, Strahler JR, Andrews PC, Jakob U (2008) Quantifying changes in the thiol redox proteome upon oxidative stress in vivo.Proc Natl Acad Sci USA 105, 8197-8202