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Dynamics of thiol-based redox switches in cellular physiology 2nd Funding Period

 

Within the SPP 1710, expertise, chosen experimental approaches, and technology is exchanged and made available in a highly synergistic way aiming to cross the borders between disciplines, between subcellular compartments, between thiol switch proteins of interest, and between model organisms – ranging from bacteria, protozoa, yeast and plants to mammals. The priority program comprises individual groups and projects approaching the joint interest in thiol switches from different angles.

 

 

Area 1: Projects characterizing selected thiol switches, which are to be studied in mechanistic, functional, and structural detail.

 

Area 2: Projects identifying as yet unknown thiol switches, which are predicted to exist in a particular functional context and are planned to be characterized.

 

Area 3: Projects developing and applying engineered thiol switches to monitor (patho)physiological redox signaling in vivo.

 

 

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Major Thiol Switches, Model Organisms and Compartments

 

Project area 1: Defined thiol switches

 

Project area 2: Unknown thiol switches

 

Project area 3: Engineered thiol switches