Expertise: ROS in cell signalling pathways and in the pathogenesis of neurodegenerative diseases, conditional knockout mice and cell systems for key enzymes of the glutathione and thioredoxin systems
Methodology provided: The Conrad group will provide expertise for the development of new in vivo models for the study of important players in thiol dependent processes. Concerning mouse analyses, the group has easy access to the German Mouse Clinic (headed by Prof. M. Hrabé de Angelis) for phenotypical and behavioral studies of transgenic mouse models. Furthermore, in vitro investigations of cell lines established from mutant mice along with highly efficient lentiviral add-back systems for the gene of interest are essential tools to study cellular and biochemical mechanisms. In addition, the group has established cell-based screening platforms for large scale drug discovery approaches (in collaboration with Dr. Joel Schick).