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Dick, Tobias Heidelberg

Expertise: Mechanisms of regulatory protein thiol oxidation and reduction; principles of glutathione redox homeostasis; the role of H2O2 in inflammatory signaling and tumorigenic proliferation

Methodology provided: The group of Tobias Dick will provide real-time redox imaging using genetically-encoded probes for the glutatione redox potential and hydrogen peroxide. These allow quantitation of redox changes by microscopy, flow cytometry and microplate assays. The group is also making available biosensor-transgenic mice, as well as methodology for redox imaging of tissue sections. For the analysis of protein thiol switches in cells, experience with tunable H2O2 generating systems (Gox/Cat) and diverse thiol trapping strategies will be contributed