Benutzerspezifische Werkzeuge


Benutzerspezifische Werkzeuge

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Meyer, Andreas Bonn

Expertise: Understanding the fundamental metabolic processes affecting the concentration and the oxidation of glutathione as well as downstream signalling processes; Arabidopsis thaliana as a model organism with a broad range of different mutants affected in glutathione biosynthesis and glutathione-dependent detoxification; to gain insight into cellular glutathione homeostasis and to understand the role of glutathione in redox signaling; development and application of genetically encoded redox probes for dynamic in vivo imaging

Methodology provided: Methods routinely applied in the Meyer lab span the full range of methods for functional analysis of plant genes with a focus on the model system Arabidopsis thaliana. A specific focus is on investigating physiological processes in living cells using fluorescence-based imaging approaches with conventional chemical probes as well as genetically encoded biosensors. In vivo fluorescence imaging applications include ratiometric imaging of EGSH, H2O2, pH and others, appropriate calibration routines and quantitative image analysis. In addition, FRET-based approaches and more recently fluorescence lifetime () of the respective fluorophore, measured by fluorescence lifetime imaging microscopy (FLIM) are used.